Objective:

To address the specific negative corneal changes, such as decreased nerve fiber density and sensitivity, associated with repeated anti-VEGF injections in AMD and DME patients and to provide comprehensive management strategies.

Key Findings:

• Corneal nerve fiber density and sensitivity significantly decrease after the third anti-VEGF injection, impacting patient comfort and recovery.
• Patients may develop neurotrophic keratitis due to corneal nerve damage, necessitating vigilant monitoring.
• Omega-3 supplementation improves corneal nerve density and tear function, supporting overall ocular health.

Interpretation:

Repeated anti-VEGF injections can lead to significant corneal nerve damage, increasing the risk of complications like neurotrophic keratitis, particularly in diabetic patients, which necessitates tailored management strategies.

Limitations:

• Limited clinical research on the effects of curcumin in humans, which may affect its recommendation.
• Need for further studies to establish long-term outcomes of interventions, highlighting the importance of evidence-based practice.

Conclusion:

Monitoring and managing corneal health in patients receiving anti-VEGF injections is crucial to prevent complications and support recovery, emphasizing the need for proactive and individualized care strategies.