5 Key Takeaways

• 1

  In a multinational cohort of nearly 74,000 men with lower urinary tract symptoms, daily tadalafil use was associated with a 22% higher relative risk of glaucoma over 5 years.

• 2

  Glaucoma developed in 3.93% of tadalafil users and 3.16% of nonusers, an absolute difference of less than 1 percentage point.

• 3

  The association was reported for primary open-angle glaucoma and ocular hypertension, but not for low-tension or angle-closure glaucoma.

• 4

  The observational study cannot establish causation or determine whether underlying vascular disease contributed to the association between tadalafil use and glaucoma.

• 5

  The article states that the findings should not prompt patients to stop tadalafil and suggests considering vascular health and eye monitoring in relevant patients.