Objective:

To highlight the importance of identifying geographic atrophy (GA) biomarkers using OCT and FAF imaging for better patient management and treatment outcomes.

Key Findings:

• RPD are associated with faster rates of GA progression and can be detected by OCT and FAF.
• Hyperreflective foci indicate pigmentary abnormalities and significantly increase the risk of GA development.
• GA appears as hypo-autofluorescent regions on FAF, indicating RPE atrophy.

Interpretation:

The use of OCT and FAF imaging provides critical insights into the risk of GA progression, enabling better patient education and management strategies.

Limitations:

• The subtlety of RPD may lead to missed diagnoses without advanced imaging.
• The reliance on imaging techniques may not be accessible to all patients.

Conclusion:

Identifying biomarkers through OCT and FAF is essential for determining which patients are at higher risk for rapid GA progression and for optimizing treatment approaches.